Heart Technology

The Heart Technology Lp(a) Binding Inhibitor is used for the following purposes:

• Lower cholesterol -- Naturally. Vitamin C is natures HMG-CoA reductase inhibitor.
• Diminish, dissolve and reverse atherosclerotic plaque by inhibiting the binding of Lp(a) to the arterial wall
• Relieve the pain of Angina Pectoris
• Reduce likelihood of blood clotting, heart attack or stroke
• Strengthen the cardiovascular system by increasing the formation of collagen
• Increase heart and other muscle strength and stamina
• Reduce blood pressure
• Reduce oxidation and inflammation.
• Replace the missing "stress" hormone
• Increase antioxidant intake and activity to slow aging
• Help natural immunity against bacterial, viral, and fungal diseases, including antibiotic-resistant strains
• Promote overall health and the feeling of well being

• Lowers Cholesterol Naturally According to Inhibition of human leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by ascorbic acid (http://www.jbc.org/cgi/content/abstract/261/16/7127) vitamin C is the original HMG-CoA reductase inhibitor.
• Dissolve atherosclerotic plaque by inhibiting the binding of Lp(a) to the arterial wall. According to the Pauling/Rath Unified Theory, and supported by US Patent #5,230,996, Lp(a) binding inhibitors increase the blood flow as plaque in the arterial wall dissolves. The patent identifies lysine, lysine analogs, e.g. proline, and vitamin C as Lp(a) binding inhibitors. These substances in concentration begin a chemical process that reverses the occlusion making the artery better able to dilate as needed. It has long been recognized that ascorbic acid (vitamin C) is in some way related to atherosclerosis. One of the great medical discoveries was of the Lysine Binding Site (LBS) on the wall of blood vessels. These binding sites are created by lesions (injury) and attract Lp(a) cholesterol which form the initial plaque deposits. Pauling and Rath put these two independent findings together and theorize that a vitamin C deficiency in human beings leads to the formation of lesions that cause Lp(a) based plaque to form. Pauling said, "Knowing that lysyl residues are what causes lipoprotein(a) to get stuck to the wall of the artery and form atherosclerotic plaques, any physical chemist would say at once that the thing to do is prevent that by putting the amino acid lysine in the blood to a greater extent than it is normally. You need lysine to be alive, it is essential: You have to get about 1 gram a day to keep in protein balance, but you can take lysine, pure lysine, a perfectly non toxic substance in food , as pills, which puts extra lysine molecules in the blood. They enter into competition with the lysyl residues on the wall of arteries and accordingly count to prevent Lp(a) from being deposited, or even will work to pull it loose and destroy atherosclerotic plaques ". Recent research at the University of Chicago discovered a new Lp(a) binding site, the Proline Binding Site, and reports that the amino acid proline may inhibit the binding of Lp(a) up to ten times more effectively than lysine in the test tube. The Lp(a) in Rhesus monkeys only binds to the proline binding site, so only proline, not lysine, can be predicted to have anti-plaque effect in these monkeys. Human Lp(a) has an affinity for both the lysine and proline binding sites.

• Relieve the pain of Angina Pectoris. Chest pain is the one symptom of heart disease that many people have prior to heart attack. This pain is a signal that the heart muscle needs more nutrients and oxygen. That oral vitamin C and lysine can reduce Angina Pectoris pain is documented by case reports, and this effect has been reported ever since Linus Pauling began recommending high dosage lysine and vitamin C in 1991. For decades doctors have recommended Nitroglycerin for Angina, not knowing why or how this substance relieves the pain. Now they do. Nitroglycerin helps create a short lived molecule in the body, Nitric Oxide (NO). NO dilates arteries, improving blood flow, and as a result Angina pain is temporarily relieved. Vitamin C/lysine work differently to relieve the pain by improving blood circulation, not by dilating arteries. Although evidence to date is largely anecdotal, there are now some studies that document this effect. Reduction in chest pain has been reported so consistently, and the substances involved are so safe , that even the great scientist Pauling said that an expensive study should not be required before people should be advised to take vitamin C and lysine.

• Reduce likelihood of blood clotting, heart attack or stroke. Vitamin E also plays a pivotal important role in the inhibition of platelet aggregation. Platelets aggregate because arachidonic acid is converted into pro-aggregatory thromboxanes; this conversion is an oxidative process responsive to vitamin E treatment. The ability of vitamin E to inhibit platelet aggregation is vitally important, as excessive, uncontrolled platelet aggregation is now acknowledged to be a primary causative factor in myocardial infarction. An ancillary mechanism involves vitamin E's ability to block redox cycling of catecholamines -the net result being a diminution in abnormal sympathetic stimulation of the heart. Due to a recent Harvard study by Rimm, et. al., orthodox medicine now recognizes the importance of vitamin E as a preventive and treatment for cardiovascular disease.

• Strengthen the cardiovascular system by increasing the formation of collagen. One important function of vitamin C is in the formation and maintenance of collagen, the basis of connective tissue, which is found in skin, ligaments, cartilage, vertebral discs, joint linings, capillary walls, and the bones and teeth. Collagen, and thus vitamin C, is needed to give support and shape to the body, to help wounds heal, and to maintain healthy blood vessels. Specifically, ascorbic acid works as a coenzyme to convert proline and lysine to hydroxyproline and hydroxylysine, both important to the collagen structure. The Pauling/Rath Unified Theory holds that it is the lack of collagen, caused by inadequate vitamin C intake, that reduces the structural integrity of human blood vessels. Weakened veins and arteries are susceptible to lesions, especially in stressful areas where blood vessels are stretched. These lesions result in the formation of atherosclerotic plaques, commonly called heart disease. Heart technology contains the three basic collagen building blocks, vitamin c, lysine and proline, that the body needs to abundantly create the collagen molecule.

• Increase muscle strength and stamina The human heart is our hardest working muscle. L-Carnitine, coenzyme Q10, magnesium, and vitamin E all interact in the mitochondrial generation of energy. Carnitine carries fats across the inner membrane for beta-oxidation. Coenzyme Q10 is the key factor in the electron transport system. Magnesium is an essential cofactor for many of the enzyme systems which support energy production. Moreover, it is required for ATP stability, as ATP is synthesized as the magnesium complex. Vitamin E is in the membrane where it can scavenge the free radicals generated by the electron transport system. L-carnitine (the rate determining factor in beta oxidation) increases ATP generation via its effects on beta oxidation, as well as its role in the removal of acetyl units from the mitochondria. The latter process is important because accumulation of acetyl units is known to inhibit various parts of the respiratory process. Other important actions of L-carnitine include vasodilatation of the blood vessels and increased ability to sustain cardiac contractions. Coenzyme Q10 is an integral part of the electron transport system, and hence regulates the ATP-generating capabilities. In addition to its well-known role in carrying electrons, recent studies have shown that coenzyme Q10 transports protons for the proton gradient used to drive oxidative phosphorylation. The latter, of course, is required for ATP synthesis. Thus, coenzyme Q10 plays a pivotal role in all energy generating systems. All organisms with an Electron Transport System have an absolute requirement for coenzyme Q10. Both animal and human studies have unequivocally proven the beneficial effects of supplementary coenzyme Q10 in numerous types of heart disease, as well as hypertension and stroke. (Heart Technology does not contain any minerals. Magnesium, a mineral, is not well tolerated by many people, so consumers are encouraged to supplement Heart Technology with ample amounts of supplemental magnesium to suit their metabolism.)

• Reduce blood and tissue lipids (fats). Ascorbic acid also helps thyroid hormone production, and it aids in cholesterol metabolism, increasing its elimination and thereby assisting in lowering blood cholesterol. Supplemental L-carnitine has been well- documented to reduce blood and tissue lipids, which is associated with a reduced risk of developing heart disease. Lipids provide 60-80% of the metabolic energy required by the heart, which explains why such high levels of L-carnitine are stored in cardiac muscle. Moreover, interference with fatty acid oxidation can have dire consequences on myocardial function. Cognizance of L-carnitine's import has led to numerous investigations, the results of which have documented its cardiovascular benefits in both animals and humans. Carnitine is perhaps best known for its lipid-lowering activity, specifically, its ability to rapidly and markedly decrease plasma triglycerides and increase HDL (good) cholesterol.

• Replaces the missing "stress" hormone. Vitamin C also aids the metabolism of tyrosine, folic acid, and tryptophan. Tryptophan is converted in the presence of ascorbic acid to 5-hydroxytryptophan, which forms serotonin, an important brain chemical. Vitamin C also helps folic acid convert to its active form, tetrahydrofolic acid, and tyrosine needs ascorbic acid to form the neurotransmitter substances dopamine and epinephrine. Vitamin C stimulates adrenal function and the release of norepinephrine and epinephrine (adrenaline), our stress hormones; however, prolonged stress depletes vitamin C in the adrenals and decreases the blood levels.

• Increase antioxidant intake and activity. Vitamin C is an antioxidant vitamin. By this function, it helps prevent oxidation of water-soluble molecules that could other-wise create free radicals, which may generate cellular injury and disease. Vitamin C also indirectly protects the fat-soluble vitamins A and E as well as some of the B vitamins, such as riboflavin, thiamine, folic acid, and pantothenic acid, from oxidation. Ascorbic acid acts as a detoxifier and may reduce the side effects of drugs such as cortisone, aspirin, and insulin; it may also reduce the toxicity of the heavy metals lead, mercury, and arsenic. Vitamin E - the major lipid-soluble antioxidant. A substantial body of evidence has accumulated on vitamin E's therapeutic as well as preventive actions against diseases of the heart and blood vessels. Supplemental vitamin E, for example, is known to decrease LDL oxidation, which reduces macrophage-mediated (inflammatory) damage to endothelial cells, thereby preventing the production of foam cells and plaque which are characteristic of atherosclerosis. By blocking inflammation, vitamin E acts as a primary defense against cardiovascular diseases.

• Help natural immunity against bacterial, viral, and fungal diseases, including antibiotic-resistant strains. Vitamin C is being shown through continued research to stimulate the immune system; through this function, along with its antioxidant function, it may help in the prevention and treatment of infections and other diseases. Ascorbic acid may activate neutrophils, the most prevalent white blood cells that work on the front-line defense in more hand-to-hand combat than other white blood cells. It also seems to increase production of lymphocytes, the white cells important in antibody production and in coordinating the cellular immune functions. In this way also, C may be helpful against bacterial, viral, and fungal diseases. In higher amounts, ascorbic acid may actually increase interferon production and thus activate the immune response to viruses; it may also decrease the production of histamine, thereby reducing immediate allergy potential. M. Levine's team at the National Institute of Health, as reported in SCIENCE, have suggested that their research indicates vitamin C is a potential weapon against antibiotic resistant bacteria.

• Promote overall health and the feeling of well being. According to Cheraskin, et. al., in THE IDEAL DAILY LYSINE INTAKE (1977) their data suggests that the healthier the subjects in their study, the greater the lysine intake. In 1992 Enstrom proved that 500 mg of vitamin C daily can extend life more than 5 years. Pauling estimated that the nutrients in Heart Technology in amounts much larger than the Recommended Daily Allowances (RDAs) might extend the period of really good health and well being 15 to 20 years.